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1

The carcinoGENOMICS project: Critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays

Mathieu Vinken, Tatyana Doktorova, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Edward Lock, Paul Carmichael, Erwin Roggen, Joost van Delft, Jos Kleinjans, José Castell, Roque Bort, Teresa Donato, M

Journal:

Mutation Research/Reviews in Mutation Research

Year:

2008

Language:

english

File:

PDF, 332 KB

english, 2008

2

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity

Heidrun Ellinger-Ziegelbauer, Jiri Aubrecht, Jos C. Kleinjans, Hans-Juergen Ahr

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 829 KB

english, 2009

3

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

Heinz, Sabrina, Freyberger, Alexius, Lawrenz, Bettina, Schladt, Ludwig, Schmuck, Gabriele, Ellinger-Ziegelbauer, Heidrun

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.71 MB

english, 2017

4

Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR

Wolfinger, Russell D., Beedanagari, Sudheer, Boitier, Eric, Chen, Tao, Couttet, Philippe, Ellinger-Ziegelbauer, Heidrun, Guillemain, Gregory, Mariet, Claire, Mouritzen, Peter, O’Lone, Raegan, Pine, P.

Journal:

BMC Biotechnology

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

5

An elastic network model to identify characteristic stress response genes

Sebastian Schneckener, Linus Görlitz, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Andreas Schuppert

Journal:

Computational Biology and Chemistry

Year:

2010

Language:

english

File:

PDF, 353 KB

english, 2010

6

Pulmonary toxicity of multi-walled carbon nanotubes (Baytubes®) relative to α-quartz following a single 6 h inhalation exposure of rats and a 3 months post-exposure period

Heidrun Ellinger-Ziegelbauer, Jürgen Pauluhn

Journal:

Year:

2009

Language:

english

File:

PDF, 1.69 MB

english, 2009

7

Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells

Heidrun Ellinger-Ziegelbauer, Hajime Karasuyama, Eitaro Yamada, Kazutake Tsujikawa, Kazuo Todokoro, Eisuke Nishida

Journal:

Year:

2000

Language:

english

File:

PDF, 284 KB

english, 2000

8

Evaluation of the rodent Hershberger bioassay: Testing of coded chemicals and supplementary molecular-biological and biochemical investigations

A. Freyberger, H. Ellinger-Ziegelbauer, F. Krötlinger

Journal:

Year:

2007

Language:

english

File:

PDF, 551 KB

english, 2007

9

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver

Heidrun Ellinger-Ziegelbauer, Barry Stuart, Brad Wahle, Werner Bomann, Hans Juergen Ahr

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 489 KB

english, 2005

10

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

Heidrun Ellinger-Ziegelbauer, Hans Gmuender, Arnd Bandenburg, Hans Juergen Ahr

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2008

Language:

english

File:

PDF, 812 KB

english, 2008

11

Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips

Kerstin Stemmer, Heidrun Ellinger-Ziegelbauer, Kerstin Lotz, Hans-J. Ahr, Daniel R. Dietrich

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 715 KB

english, 2006

12

Toxicogenomic analysis of N-nitrosomorpholine induced changes in rat liver: Comparison of genomic and proteomic responses and anchoring to histopathological parameters

A. Oberemm, H.-J. Ahr, P. Bannasch, H. Ellinger-Ziegelbauer, M. Glückmann, J. Hellmann, C. Ittrich, A. Kopp-Schneider, P.-J. Kramer, E. Krause, M. Kröger, E. Kiss, H.-B. Richter-Reichhelm, G. Scholz,

Journal:

Toxicology and Applied Pharmacology

Year:

2009

Language:

english

File:

PDF, 3.45 MB

english, 2009

13

The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury

Heidrun Ellinger-Ziegelbauer, Melanie Adler, Alexander Amberg, Arnd Brandenburg, John J. Callanan, Susan Connor, Michael Fountoulakis, Hans Gmuender, Albrecht Gruhler, Philip Hewitt, Mark Hodson, Katj

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.59 MB

english, 2011

14

EU Framework 6 Project: Predictive Toxicology (PredTox)—overview and outcome

Laura Suter, Susanne Schroeder, Kirstin Meyer, Jean-Charles Gautier, Alexander Amberg, Maria Wendt, Hans Gmuender, Angela Mally, Eric Boitier, Heidrun Ellinger-Ziegelbauer, Katja Matheis, Friedlieb Pf

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

15

Testosterone response of hepatic gene expression in female mice having acquired testosterone-unresponsive immunity to Plasmodium chabaudi malaria

D. Delić, H. Ellinger-Ziegelbauer, H.W. Vohr, M. Dkhil, S. Al-Quraishy, F. Wunderlich

Journal:

Year:

2011

Language:

english

File:

PDF, 502 KB

english, 2011

16

Characterization of primary rat proximal tubular cells by gene expression analysis

C. Weiland, H.J. Ahr, H.W. Vohr, H. Ellinger-Ziegelbauer

Journal:

Toxicology in Vitro

Year:

2007

Language:

english

File:

PDF, 739 KB

english, 2007

17

Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion

Paul Jennings, Sonia Aydin, Jason Bennett, Rachael McBride, Christina Weiland, Niamh Tuite, Leonhard N. Gruber, Paul Perco, Peadar Ó Gaora, Heidrun Ellinger-Ziegelbauer, Hans-Juergen Ahr, Cees Van Koo

Journal:

Toxicology in Vitro

Year:

2009

Language:

english

File:

PDF, 1.25 MB

english, 2009

18

Assessment of candidate biomarkers of drug-induced hepatobiliary injury in preclinical toxicity studies

M. Adler, D. Hoffmann, H. Ellinger-Ziegelbauer, P. Hewitt, K. Matheis, L. Mulrane, W.M. Gallagher, J.J. Callanan, L. Suter, M.M. Fountoulakis, W. Dekant, A. Mally

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

19

Molecular Characterization of Preneoplastic Lesions Provides Insight on the Development of Renal Tumors

Kerstin Stemmer, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Daniel R. Dietrich

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 2.13 MB

english, 2009

20

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

Tatyana Y. Doktorova, Heidrun Ellinger-Ziegelbauer, Mathieu Vinken, Tamara Vanhaecke, Joost van Delft, Jos Kleinjans, Hans-Juergen Ahr, Vera Rogiers

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 871 KB

english, 2012

21

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

Markus Schug, Regina Stöber, Tanja Heise, Hans Mielke, Ursula Gundert-Remy, Patricio Godoy, Raymond Reif, Meinolf Blaszkewicz, Heidrun Ellinger-Ziegelbauer, Hans-Jürgen Ahr, Silvia Selinski, Georgia G

Journal:

Archives of Toxicology

Year:

2013

Language:

english

File:

PDF, 447 KB

english, 2013

22

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data

Tatyana Y. Doktorova, Heidrun Ellinger-Ziegelbauer, Mathieu Vinken, Tamara Vanhaecke, Joost van Delft, Jos Kleinjans, Hans-Juergen Ahr, Vera Rogiers

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 523 KB

english, 2012

23

Hershberger assay: Testing of coded chemicals and supplementary molecular and biochemical investigations

A. Freyberger, H. Ellinger-Ziegelbauer, A. Brockes, F. Krötlinger

Journal:

Toxicology Letters

Year:

2006

Language:

english

File:

PDF, 103 KB

english, 2006

24

Characteristic expression profiles induced by carcinogens in rat liver

H. Ellinger-Ziegelbauer, H.-J. Ahr, H. Gmuender, C. Pallez, J. Koenig

Journal:

Toxicology Letters

Year:

2006

Language:

english

File:

PDF, 89 KB

english, 2006

25

Application of toxicogenomics in studies on the hepatotoxicity or nephrotoxicity of carcinogens

Hans Juergen Ahr, Heidrun Ellinger-Ziegelbauer

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 56 KB

english, 2008

26

The pattern of retinoic acid receptor γ (RARγ) expression in normal development of Xenopus laevis and after manipulation of the main body axis

Ellinger-Ziegelbauer, Heidrun, Dreyer, Christine

Journal:

Mechanisms of Development

Year:

1993

Language:

english

File:

PDF, 1.57 MB

english, 1993

27

Comparison of the Mesoscale Discovery and Luminex multiplex platforms for measurement of urinary biomarkers in a cisplatin rat kidney injury model

Pavkovic, Mira, Riefke, Björn, Gutberlet, Katrin, Raschke, Marian, Ellinger-Ziegelbauer, Heidrun

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

28

The HESI inter-laboratory miRNA project

Thompson, K.L., Chen, T., Couttet, P., Ellinger-Ziegelbauer, H., Kanki, M., Kelsall, J., Boitier, E., Nassirpour, R., Searfoss, G., Sharapova, T., de la Moureyre-Spire, Catherine, Yuen, P., O’Lone, R.

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 63 KB

english, 2013

29

Multi-laboratory assessment of best practices for quantification of microRNAs associated with isoproterenol-induced myocardial injury in the urine and plasma of rats

Thompson, KL, Chen, T, Couttet, P, Ellinger-Ziegelbauer, H, Kanki, M, Kelsall, J, Boitier, E, Nassirpour, R, Searfoss, G, Sharapova, T, de la Moureyre-Spire, C, Yuen, P, O’Lone, R

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 81 KB

english, 2013

30

Urinary microRNA profiling for identification of biomarkers after cisplatin-induced kidney injury

Pavkovic, Mira, Riefke, Björn, Ellinger-Ziegelbauer, Heidrun

Journal:

Year:

2014

Language:

english

File:

PDF, 2.76 MB

english, 2014

31

Drug induced changes in the mouse liver epigenome

Meehan, Richard, Lempiäinen, Harri, Braeuning, Albert, Müller, Arne, Vitobello, Antonio, Ellinger-Ziegelbauer, Heidrun, Henderson, Colin, Schwarz, Michael, Terranova, Rémi, Moggs, Jonathan, Wolf, C. R

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 59 KB

english, 2014

32

Early microRNA and other non-coding RNA biomarkers for rodent non-genotoxic carcinogens

Ellinger-Ziegelbauer, Heidrun, Toft, Dorthe Bach, Braeuning, Albert, Couttet, Philippe, DaCosta, Andre, Dhalluin, Stephane, Eichner, Johannes, Elcombe, Clifford R., Grenet, Olivier, Henderson, Colin,

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 58 KB

english, 2014

33

Application of RNA interference to improve mechanistic understanding of omics responses to a hepatotoxic drug in primary rat hepatocytes

Adler, M., Leich, E., Ellinger-Ziegelbauer, H., Hewitt, P., Dekant, W., Rosenwald, A., Mally, A.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.23 MB

english, 2014

34

Glomerulonephritis-Induced Changes in Urinary and Kidney MicroRNA Profiles in Rats

Pavkovic, M., Riefke, B., Frisk, A.-L., Groticke, I., Ellinger-Ziegelbauer, H.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 1.43 MB

english, 2015

35

Carcinogen-Specific Gene Expression Profiles in Short-term Treated Eker and Wild-type Rats Indicative of Pathways Involved in Renal Tumorigenesis

Stemmer, K., Ellinger-Ziegelbauer, H., Ahr, H.-J., Dietrich, D. R.

Journal:

Cancer Research

Year:

2007

Language:

english

File:

PDF, 874 KB

english, 2007

36

Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2

Leonardi, A., Ellinger-Ziegelbauer, H., Franzoso, G., Brown, K., Siebenlist, U.

Journal:

Journal of Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 806 KB

english, 2000

37

FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis.

Ellinger-Ziegelbauer, H, Hihi, A K, Laudet, V, Keller, H, Wahli, W, Dreyer, C

Journal:

Molecular and Cellular Biology

Year:

1994

Language:

english

File:

PDF, 3.06 MB

english, 1994

38

Characteristic Expression Profiles Induced by Genotoxic Carcinogens in Rat Liver

Ellinger-Ziegelbauer, H.

Journal:

Toxicological Sciences

Year:

2003

Language:

english

File:

PDF, 472 KB

english, 2003

39

Direct Activation of the Stress-activated Protein Kinase (SAPK) and Extracellular Signal-regulated Protein Kinase (ERK) Pathways by an Inducible Mitogen-activated Protein Kinase/ERK Kinase Kinase 3 (MEKK) Derivative

Ellinger-Ziegelbauer, H., Brown, K., Kelly, K., Siebenlist, U.

Journal:

Journal of Biological Chemistry

Year:

1997

Language:

english

File:

PDF, 870 KB

english, 1997

40

A retinoic acid receptor expressed in the early development of Xenopus laevis.

Ellinger-Ziegelbauer, H, Dreyer, C

Journal:

Genes & Development

Year:

1991

Language:

english

File:

PDF, 2.34 MB

english, 1991

41

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

H. Ellinger-ziegelbauer, J. M. Fostel, C. Aruga, D. Bauer, E. Boitier, S. Deng, D. Dickinson, A. Le Fevre, A. J. Fornace, O. Grenet, Y. Gu, J. Hoflack, M. Shiiyama, R. Smith, R. D. Snyder, C. Spire, G

Year:

2009

Language:

english

File:

PDF, 681 KB

english, 2009

42

In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

Heise, T., Schug, M., Storm, D., Ellinger-Ziegelbauer, H., J. Ahr, H., Hellwig, B., Rahnenführer, J., Ghallab, A., Guenther, G., Sisnaiske, J., Reif, R., Godoy, P., Mielke, H., Gundert-Remy, U., Lampe

Journal:

Current Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 342 KB

english, 2012

43

A naturally occurring short variant of the FTZ-F1-related nuclear orphan receptor xFF1rA and interactions between domains of xFF1rA.

Ellinger-Ziegelbauer, H, Gläser, B, Dreyer, C

Journal:

Molecular Endocrinology

Year:

1995

Language:

english

File:

PDF, 2.52 MB

english, 1995

44

Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute

Miousse, Isabelle R., Currie, Richard, Datta, Kaushik, Ellinger-Ziegelbauer, Heidrun, French, John E., Harrill, Alison H., Koturbash, Igor, Lawton, Michael, Mann, Derek, Meehan, Richard R., Moggs, Jon

Journal:

Year:

2015

Language:

english

File:

PDF, 1.22 MB

english, 2015

45

Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats

Church, Rachel J., Otieno, Monicah, McDuffie, James Eric, Singh, Bhanu, Sonee, Manisha, Hall, LeRoy, Watkins, Paul B., Ellinger-Ziegelbauer, Heidrun, Harrill, Alison H.

Journal:

Toxicological Sciences

Year:

2015

Language:

english

File:

PDF, 615 KB

english, 2015

46

Glomerulonephritis-induced changes in kidney gene expression in rats

Pavkovic, Mira, Riefke, Björn, Frisk, Anna-Lena, Gröticke, Ina, Ellinger-Ziegelbauer, Heidrun

Journal:

Year:

2015

Language:

english

File:

PDF, 151 KB

english, 2015

47

Cell Cycle Arrest and Reversion of Ras-Induced Transformation by a Conditionally Activated Form of Mitogen-Activated Protein Kinase Kinase Kinase 3

Ellinger-Ziegelbauer, Heidrun, Kelly, Kathleen, Siebenlist, Ulrich

Journal:

Molecular and Cellular Biology

Year:

1999

Language:

english

File:

PDF, 3.25 MB

english, 1999

48

The Role of Residual Gadolinium in the Induction of Nephrogenic Systemic Fibrosis-Like Skin Lesions in Rats

Pietsch, Hubertus, Raschke, Marian, Ellinger-Ziegelbauer, Heidrun, Jost, Gregor, Walter, Jakob, Frenzel, Thomas, Lenhard, Diana, Hütter, Joachim, Sieber, Martin A.

Journal:

Investigative Radiology

Year:

2011

Language:

english

File:

PDF, 1.43 MB

english, 2011

49

Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites

Thompson, Karol L., Boitier, Eric, Chen, Tao, Couttet, Philippe, Ellinger-Ziegelbauer, Heidrun, Goetschy, Manuela, Guillemain, Gregory, Kanki, Masayuki, Kelsall, Janet, Mariet, Claire, de La Moureyre–

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 539 KB

english, 2016

50

Mitochondrial complex I inhibitors: Mechanistic investigations in the context of safety evaluation

Heinz, S., Ellinger-Ziegelbauer, H., Schladt, L., Lawrenz, B., Freyberger, A., Schmuck, G.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 67 KB

english, 2015